HGP Research Area: Chromosome Mapping
One of the key research areas of the HGP was chromosome mapping.
Mapping is the construction of a series of chromosome descriptions that depict the position and spacing of unique, identifiable biochemical landmarks, including some genes, that occur on the DNA of chromosomes.
In 1990, DOE initiated projects to enrich the developing chromosome maps with markers for genes. In 1993 this effort led to the establishment of the Integrated Molecular Analysis of Gene Expression (IMAGE) Consortium. IMAGE members developed and arrayed cDNA clones (representing the gene coding regions of the genome) to make them available worldwide. In 2007, the effort was transferred to HudsonAlpha. Numerous other institutes and identities have undertaken mapping efforts.
| Area | HGP Goal | Standard Achieved | Date Achieved |
|---|---|---|---|
| Genetic Map | 2- to 5-cM resolution map (600 – 1,500 markers) | 1-cM resolution map (3,000 markers) | September 1994 |
| Physical Map | 30,000 STSs | 52,000 STSs | October 1998 |
| Gene Identification | Full-length human cDNAs | 15,000 full-length human cDNAs | March 2003 |
For a more detailed explanation of mapping, see the U.S. DOE Primer on Molecular Genetics.
Abstracts
- Mapping abstracts from 2000 U.S. DOE Human Genome Program Contractor-Grantee Workshop VIII
- Mapping abstracts from 1999 U.S. DOE Human Genome Program Contractor-Grantee Workshop VII
- Mapping and Resources abstracts from 1997 U.S. DOE Human Genome Program Contractor-Grantee Workshop VI
- Mapping abstracts from U.S. DOE Human Genome 1997 Program Report
- Mapping abstracts from 1996 U.S. DOE Human Genome Program Contractor-Grantee Workshop V
- “Five Years of Progress in the U.S. Human Genome Project: Genetic and Physical Mapping” (Human Genome News: December 1995)
- Mapping abstracts from 1994 U.S. DOE Human Genome Program Contractor-Grantee Workshop IV
- Abstracts from 1993 U.S. DOE Human Genome Program Contractor-Grantee Workshop III (see Subject Index for Mapping abstracts)
- Physical and Genetic Mapping abstracts from U.S. DOE Human Genome 1993 Program Report
- Mapping Instrumentation abstracts from U.S. DOE Human Genome 1993 Program Report
- Physical and Genetic Mapping abstracts from U.S. DOE Human Genome 1991-92 Program Report
- Mapping Speaker and Poster abstracts from 1991 U.S. DOE Human Genome Program Contractor-Grantee Workshop II
- Mapping abstracts from U.S. DOE Human Genome 1989-90 Program Report
- Abstracts from 1989 U.S. DOE Human Genome Program Contractor-Grantee Workshop I
Gene Maps
- NCBI Human Genome Map Viewer (now Genome Data Viewer)
- A Gene Map of the Human Genome (1998/1999)
- A Gene Map of the Human Genome (1996)
- Gene Gateway
Single Chromosome Workshops
- Revised U.S. Policy for Support of Single Chromosome Workshops (March 1995)
- Citations of Workshop Reports